More than 200 human viruses have been reported, and they use sophisticated and diverse strategies to infect the human body. The search for the receptors used by viruses to invade cells has long been devoted to trying to understand the first steps of viral infection. However, studies conducted from different perspectives do not reflect the full picture and commonality of these receptor molecules. In this study, we integrated genomic, transcriptomic, and epitranscriptome data to establish a multi-omics joint analysis platform, GateView, to demonstrate the multifaceted characteristics of each viral receptor, including expression characteristics, DNA variants and RNA modifications, homologous gene distribution, and codon usage preferences in different populations, tissues, cells, and developmental stages of the receptors. Taking the coronavirus family as an example, we have used the GateView platform to analyze the relationship between viral receptor molecules and other factors in host cells in detail, including co-expression characteristics among receptor molecules and the relationship between codon usage preferences and highly expressed genes in tissues, taking into account the infection characteristics of viruses. The above studies provide an important data resource for revealing the mechanism of virus invasion into the host and subsequent drug development.

receptor,virus,tissue,deep sequenc,bioinformatics